Born in Osterburg, Germany, Samuel Seidenberg studied in Berlin at the „Hanns Eisler” School of Music Berlin with prof. Friedrich Dallmann.

Between 1998 and 2006 he was the principal horn of the Bamberger Symphonikern, Münchner Philharmoniker, DSO Berlin and Nürnberger Philharmonikern,  followed by HR Frankfurt between 2006 and 2018.

He has colaborated with Berliner Philharmoniker,  NDR Hamburg, BR München, WDR Köln and the Teatro alla Scalla Orchestra from Milano.

As a soloist, he appeared on stage with Berliner and Münchner Kammerorchester, HR Frankfurt, Bamberger Symphonikern and the Prague Philharmonic Orchestra under conductors like Paavo Järvi, Sebastian Weigle, Jonathan Nott and Christoph Poppen.

In 2004, Samuel Seidenberg won the International Competition in Geneva.

Starting with 2013, he is a horn teacher at the Mannheim University of Music and Performing Arts.